White matter integrity in hair-pulling disorder (trichotillomania).
نویسندگان
چکیده
Hair-pulling disorder (trichotillomania, HPD) is a disabling condition that is characterized by repetitive hair-pulling resulting in hair loss. Although there is evidence of structural grey matter abnormalities in HPD, there is a paucity of data on white matter integrity. The aim of this study was to explore white matter integrity using diffusion tensor imaging (DTI) in subjects with HPD and healthy controls. Sixteen adult female subjects with HPD and 13 healthy female controls underwent DTI. Hair-pulling symptom severity, anxiety and depressive symptoms were also assessed. Tract-based spatial statistics were used to analyze data on fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). There were no differences in DTI measures between HPD subjects and healthy controls. However, there were significant associations of increased MD in white matter tracts of the fronto-striatal-thalamic pathway with longer HPD duration and increased HPD severity. Our findings suggest that white matter integrity in fronto-striatal-thalamic pathways in HPD is related to symptom duration and severity. The molecular basis of measures of white matter integrity in HPD deserves further exploration.
منابع مشابه
اثربخشی درمان تنظیم هیجانی بر شدت علائم، اضطراب، افسردگی، استرس و کیفیت زندگی در افراد مبتلا به اختلال کندن مو
Background and Aim: Trichotillomania (hair pulling disorder) is a chronic disorder, characterized by frequent hair pulling leading to hair loss. This disorder despite having multiple physical, economic and social consequences, is less likely to be diagnosed and treated. In the present study, we investigated the efficacy of emotion regulation therapy (ERT) on symptom’s severity, anxiety, depress...
متن کاملTrichotillomania in a dementia case
We report an 87-year-old male case of hair pulling associated with a white-matter vascular dementia (Binswanger's disease). Trichotillomania in our case did not resolve using mirtazapine or anticholinesterasic medication. Trichotillomania seems to be related to a form of perseveration associated with dementia. The findings in this case suggest the abnormality involving white matter in the patho...
متن کاملGrey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
BACKGROUND Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking. AIMS To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania. METHOD Eighteen patients with DSM-IV trichotillomania and 19 healthy contr...
متن کاملAuditory Hallucinations with an Unusual Content.
Recurrent hair pulling resulting in hair loss, in the absence of a medical or another mental disorder is a diagnostic feature of trichotillomania. It is commonly seen in depression and many other psychiatric disorders. Trichotillomania rarely occurs as a co morbid condition in patients with schizophrenia. Even rarer is recurrent hair pulling in response to psychotic symptoms in schizophrenia. W...
متن کاملThe Phenomenology of Hair Pulling Urges in Trichotillomania: A Comparative Approach
Trichotillomania is a disorder characterized by recurrent urges to pull out one's hair, but the experiential characteristics of hair pulling urges are poorly understood. This study used a comparative approach to understand the subjective phenomenology of hair pulling: participants with trichotillomania symptoms were asked about their hair pulling urges as well as their urges to eat unhealthy fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Psychiatry research
دوره 211 3 شماره
صفحات -
تاریخ انتشار 2013